Farmaseuttisen kemian laitos
Department of Pharmaceutical Chemistry

Julkaisut 2009
Publications 2009

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1 Eckardt K et al. Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle.
2 Gynther M et al. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.
3 Huttunen K. Novel Prodrug Structures for Improved and Targeted Drug Delivery. Design, Synthesis, and in Vitro / in Vivo Evaluation .
4 Huttunen KM et al. The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.
5 Huttunen KM et al. Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.
6 Häkkinen MR et al. Synthesis of novel deuterium labelled derivates of N-alkylated polyamines.
7 Jauhiainen M et al. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry.
8 Kalliokoski T et al. The effect of ligand-based tautomer and protomer prediction on structure-based virtual screening.
9 Keski-Rahkonen P et al. Atmospheric pressure thermospray ionization using a heated microchip nebulizer.
10 Kiviranta PH et al. N(epsilon)-Thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
11 Kultti A et al. 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
12 Laine JE et al. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.
13 Malinen H et al. Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats.
14 Mannila A. Central Nervous System Permeation of Ibuprofen, Ketoprofen and Indomethacin. In Vivo and In Situ Studies in Rats and Clinical Trials in Children.
15 Mannila J et al. Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate.
16 Matero S et al. The feasibility of using acoustic emissions for monitoring of fluidized bed granulation.
17 Matero S et al. Monitoring the wetting phase of fluidized bed granulation process using multi-way methods: The separation of successful from unsuccessful batches.
18 Matilainen L et al. The stability and dissolution properties of solid glucagon/gamma-cyclodextrin powder.
19 Minkkilä A et al. The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.
20 Minkkilä A et al. Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.
21 Myllymäki MJ et al. Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and interaction fields.
22 Paakkunainen M et al. Uncertainty in dissolution test of drug release.
23 Partanen HA et al. Aflatoxin B1 transfer and metabolism in human placenta.
24 Qu C-J et al. Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension.
25 Reux B et al. Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor.
26 Räikkönen J et al. Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro.
27 Rönkkö T. Brutus. A Molecular Energy Field Based Superposition Algorithm for Virtual Screening.
28 Stenman SM et al. Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease.
29 Tiikkainen P et al. Critical comparison of virtual screening methods against the MUV data set.
30 Tiikkainen P et al. Comparison of structure fingerprint and molecular interaction field based methods in explaining biological simularity of small molecules in cell-based screens.
31 Toivanen M et al. Binding of Neisseria meningtidis pili to berry polyphenolic fractions.
32 Wasdo SC et al. A comparison of the fit of flux through hairless mouse skin from water data to three model equations.

Farmaseuttisen kemian laitos Department of Pharmaceutical Chemistry
Julkaisutietokanta 27.5.2010 Publications Data Base 27.5.2010