Farmaseuttisen kemian laitos
Department of Pharmaceutical Chemistry

Julkaisut 2008
Publications 2008

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1 Annola K et al. Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta.
2 Annola K et al. Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry.
3 Gynther M et al. Large neutral amino acid transporter enables brain drug delivery via prodrugs.
4 Hakulinen MA et al. Ultrasound transmission technique as a potential tool for physical evaluation of monolithic matrix tablets.
5 Huhtiniemi T et al. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.
6 Huttunen KM et al. Towards metformin prodrugs.
7 Huttunen KM et al. Cytochrome P450-activated prodrugs: targeted drug delivery.
8 Häkkinen MR et al. Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.
9 Jarho P. Lääkepäivät - Lääkkeitä myös terveille? 25.-26.4.2008 Kuopio.
10 Jokela TA et al. Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines.
11 Juntunen J et al. The effect of water solubility of solutes on their flux through human skin in vitro: A prodrug database integrated into the extended Flynn database.
12 Jyrkkärinne J et al. Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship.
13 Kalliokoski T et al. FieldChopper, a new tool for automatic model generation and virtual screening based on molecular fields.
14 Kiviranta P. Design and Synthesis of Silent Information Regulator Human Type 2 (SIRT2) Inhibitors.
15 Kiviranta PH et al. Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.
16 Kokki H et al. Diclofenac readily penetrates the cerebrospinal fluid in children.
17 Koponen JM et al. Characterization and fate of black currant and bilberry flavonols in enzyme-aided processing.
18 Korjamo T et al. Effect of N-betainate and N-piperazine derivatives of chitosan on the paracellular transport of mannitol in Caco-2 cells.
19 Kumpulainen E et al. How readily does ketorolac penetrate cerebrospinal fluid in children?
20 Kumpulainen H et al. Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.
21 Küblbeck J et al. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor.
22 Lehtonen M et al. Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes.
23 Matero S et al. Estimation of drug release profiles of a heterogeneous set of drugs from a hydrophobic matrix tablet using molecular descriptors.
24 Matilainen L. Cyclodextrins in Peptide Delivery. In vitro Studies for Injectable and Inhaled Formulations.
25 Matilainen L. Syklodekstriinit peptidien annossa: in vitro -tutkimuksia injektoitavia ja inhaloitavia formalaatioita varten.
26 Matilainen L et al. The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes.
27 Matilainen L et al. In vitro toxicity and permeation of cyclodextrins in Calu-3 cells.
28 Minkkilä A et al. Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
29 Másson M et al. Antimicrobial activity of piperazine derivatives of chitosan.
30 Mönkkönen H et al. Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth.
31 Oikari S et al. Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.
32 Pohjala L et al. A luciferase-based screening method for inhibitors of alphavirus replication applied to nucleoside analogues.
33 Poso A, Huffman JW. Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands .
34 Pulkkinen M et al. High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone.
35 Rahnasto M et al. Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme-an in silico approach.
36 Raunio H et al. Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo.
37 Rautio J et al. Prodrugs: design and clinical applications.
38 Rautio J et al. Enhanced brain drug delivery and targeting.
39 Rúnarsson ÖV et al. N-selective "one pot" synthesis of highly N-substituted trimethyl chitosan (TMC).
40 Saarelainen S et al. Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity.
41 Salminen A et al. Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential.
42 Tennilä T et al. Peptide-oligonucleotide conjugates form stable and selective complexes with antibody and DNA .
43 Toropainen T. Cyclodextrins and Their Solid-State Complexes. Studies for Pulmonary Drug Delivery.
44 Toropainen T. Syklodekstriinit ja niiden kiinteät kompleksit: Tutkimuksia keuhkoantoa varten.
45 Toropainen T et al. Quantitative analysis of natural cyclodextrins by high-performance liquid chromatography with pulsed amperometric detection: Application to cell permeation study.
46 Turunen E et al. Development and validation of a gas chromatographic-mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration.
47 Wasdo S et al. Modeling of flux through silicone membranes from water.

Farmaseuttisen kemian laitos Department of Pharmaceutical Chemistry
Julkaisutietokanta 27.8.2009 Publications Data Base 27.8.2009