Farmaseuttisen kemian laitos
Department of Pharmaceutical Chemistry

Julkaisut 2000
Publications 2000

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1 Ahlmark MJ et al. Bisphosphonate prodrugs: unusual dimerisation of clodronic acid trimethyl ester to a cyclic bis(bisphosphonate).
2 Antopolsky M, Azhayev A. Stepwise solid-phase synthesis of peptide-oligonucleotide conjugates on new solid supports.
3 Antopolsky M, Azhayev A. Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry.
4 Elo MA et al. Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells.
5 Faivre V et al. Ligand interaction with the purified serotonin transporter in solution and at the air/water interface.
6 Hämäläinen KM et al. Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye.
7 Jarho P, Järvinen T. Syklodekstriinit - perustutkimuksesta lääkkeisiin.
8 Jarho P et al. Cyclodextrin-catalyzed deacetylation of spironolactone is pH and cyclodextrin dependent.
9 Juvonen RO et al. Pronounced differences in inhibition potency of lactone and non-lactone compounds for mouse and human coumarin 7-hydroxylases (CYP2A5 and CYP2A6).
10 Kovalainen JT. Intramolecular Hydrogen Bonding in Histamine H3-Receptor Activation. Synthesis, NMR Studies and SAR of a Series of H3-Receptor Ligands.
11 Kovalainen JT et al. A proton relay process as the mechanism of activation of the histamine H3-receptor determined by 1H NMR and ab initio quantum mechanical calculations.
12 Kovalainen JT et al. 2(S)-Amino-3-[1H-imidazol-4(5)-yl]propyl cyclohexylmethyl ether dihydrochloride and 2(S)-amino-3-[1H-imidazol-4(5)-yl]propyl 4-bromobenzyl ether dihydrochloride.
13 Leppänen J et al. Synthesis of a water-soluble prodrug of entacapone.
14 Mönkkönen H et al. Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry.
15 Niemi R. Bisphosphonate Prodrugs - Synthesis and in Vitro Evaluation of Novel Clodronic and Etidronic acid Derivatives.
16 Niemi R et al. Bisphosphonate prodrugs: synthesis and in vitro evaluation of alkyl and acyloxymethyl esters of etidronic acid as bioreversible prodrugs of etidronate.
17 Pellinen P et al. Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.
18 Pohjala EK et al., keksijä. Uudet metyleenibisfosfonihappojohdannaiset.
19 Päivärinta J et al. Calculated and measured vibrational frequencies in an alkanoic acid-alkylamine complex.
20 Rautio J. Synthesis and in Vitro Evaluation of Novel Naproxen and Ketoprofen Prodrugs for Topical Drug Delivery.
21 Rautio J. Aihiolääkkeet parantavat lääkeaineen ihonläpäisevyyttä.
22 Rautio J et al. Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery.
23 Rautio J et al. Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation.
24 Savolainen J. Improvement of the Physicochemical Properties and Oral Bioavailability of Poorly Bioavailable Drugs by Cyclodextrin- and Prodrug-Technology.
25 Savolainen J. Syklodekstriini- ja aihiolääke-teknologiat parantavat lääkeaineiden ominaisuuksia ja hyötyosuutta.
26 Savolainen J et al. Effects of aqueous solubility and dissolution characteristics on oral bioavailability of entacapone .
27 Savolainen J et al. Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone.
28 Suihko E et al. Deformation behaviors of tolbutamide, hydroxypropyl-beta-cyclodextrin, and their dispersions.
29 Tennilä T et al. Oligonucleotides containing 9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-adenine and -guanine: synthesis, hybridization and antisense properties.
30 Tiihonen J et al. Weather conditions and violent behavior.
31 Turhanen PA et al. Bisphosphonate prodrugs: selective synthesis of (1-hydroxyethylidene)-1,1-bisphosphonate partial esters.

Farmaseuttisen kemian laitos Department of Pharmaceutical Chemistry
Julkaisutietokanta 15.4.2008 Publications Data Base 15.4.2008