structural biology      

 

Juha Rouvinen


Born 1960, M.Sc. 1986 (University of Joensuu), Ph.Lic. 1987, Graduate student (University of Uppsala) 1987-1990, PhD 1991 (University of Joensuu), Docent 1993 (University of Kuopio), Senior Assistant (University of Joensuu) 1993-1996, Senior Researcher (Academy of Finland) 1996-2001, Professor (University of Joensuu) 2001-. Dean of the Faculty 2007-2009.

Research interests

Three-dimensional structures and functional mechanisms of proteins

Selected publications

Rouvinen J, Bergfors T, Teeri T, Knowles J & Jones TA: Three-Dimensional Structure of Cellobiohydrolase II from Trichoderma reesei. Science 249 (1990) 380-386.

Törrönen A, Harkki A & Rouvinen J: Crystallographic studies on endo-1,4-b-xylanase II from Trichoderma reesei: two conformational states in the active site. EMBO J. 13 (1994) 2493-2501.

Oinonen C, Tikkanen R, Rouvinen J & Peltonen L: Three-dimensional structure of human lysosomal aspartylglucosaminidase. Nature Struct. Biol. 2 (1995) 1102-1108.

Rouvinen J, Rautiainen J, Virtanen, T, Zeller T, Kauppinen J, Taivainen A & Mäntyjärvi R: Probing the molecular basis of allergy. Three-dimensional structure of major bovine allergen Bos d 2. J. Biol. Chem. 274 (1999) 2337-2343.

Valjakka JM, Hemminki A, Niemi S, Söderlund H, Takkinen K & Rouvinen J: Crystal structure of an in vitro affinity and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains. J. Biol. Chem. 277 (2002) 44021-44027.

Hakulinen N, Kiiskinen L-L, Kruus K, Saloheimo M, Koivula A & Rouvinen J: Crystal structure of a laccase from Melanocarpus albomyces with an intact trinuclear copper site. Nature Struct. Biol.9 (2002) 601-605.

Hakanpää J, Linder M, Askolin S, Nakari-Setälä T, Parkkinen T, Penttilä M & Rouvinen J: Atomic resolution structure of the HFBII hydrophobin: a self-assembling amphiphile. J. Biol. Chem. 279 (2004) 527-533.

Niemi M, Jylhä S, Laukkanen M-L, Söderlund H, Mäkinen-Kiljunen S, Kallio JM, Hakulinen N, Haahtela T, Takkinen K & Rouvinen J: Molecular interactions between a recombinant IgE antibody and the b-lactoglobulin allergen. Structure, 15 (2007) 1413-1421.