A.I. Virtanen -instituutti
A.I. Virtanen Institute for Molecular Sciences

Julkaisut 2000
Publications 2000

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1 Airenne KJ et al. Baculovirus-mediated periadventitial gene transfer to rabbit carotid artery.
2 Alhonen L et al. Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
3 Björklund M et al. Overexpression of alpha2C-adrenoceptors impairs water maze navigation.
4 Brigelius-Flohé R et al. Overexpression of PHGPx inhibits hydroperoxide-induced oxidation, NFkappaB activation and apoptosis and affects oxLDL-mediated proliferation of rabbit aortic smooth muscle cells.
5 Coffey ET et al. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.
6 Diez M et al. Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein - initial observations.
7 Erkkilä AT et al. Autoantibodies against oxidized low-density lipoprotein and cardiolipin in patients with coronary heart disease.
8 Galuske RAW et al. Differential effects of neurotrophins on ocular dominance plasticity in developing and adult cat visual cortex.
9 Gröhn O. Magnetic Resonance Imaging of Acute Cerebral Ischaemia. Novel Haemodynamic and Parenchymal Indicators of Reversible and Irreversible Ischaemia.
10 Gröhn OHJ et al. Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho.
11 Gröhn OHJ et al. Graded reduction of cerebral blood flow in rat as detected by the nuclear magnetic resonance relaxation time T2: a theoretical and experimental approach.
12 Haapalinna A et al. The effects of a specific alpha2-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats .
13 Hakumäki JM, Kauppinen RA. 1H NMR visible lipids in the life and death of cells.
14 Hakumäki JM et al. Reduction in water and metabolite apparent diffusion coefficients during energy failure involves cation-dependent mechanisms. A proton nuclear magnetic resonance study of rat cortical brain slices.
15 Hakumäki JM et al. Geenihoidolla aikaansaadun apoptoosin havaitseminen käyttäen 1H-magneettispektroskopiaa in vivo.
16 Hedman M, Ylä-Herttuala S. Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
17 Heikkinen S et al. Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern.
18 Hiltunen MO. Gene Expression in Atherosclerotic Lesions and Therapeutic Strategies Using Gene Transfer.
19 Hiltunen MO et al. Intravascular adenovirus-mediated VEGF-C gene transfer reduces noeintima formation in balloon-denuded rabbit aorta.
20 Hiltunen MO et al. Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer.
21 Hiltunen MO et al. Biodistribution of adenoviral vector to nontarget tissues after local in vivo gene transfer to arterial wall using intravastular and periadventitial gene delivery methods.
22 Häkkinen T. Inflammatory Cells and Mediators in Atherosclerotic Lesions.
23 Häkkinen T et al. Macrophages, smooth muscle cells, endothelial cells, and T-cells express CD40 and CD40L in fatty streaks and more advanced human atherosclerotic lesions.
24 Jolkkonen J et al. MAO-B inhibition by a single dose of l-Deprenyl or Lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.
25 Jortikka MO et al. The role of microtubules in the regulation of proteoglycan synthesis in chondrocytes under hydrostatic pressure.
26 Kaasinen K et al. Overexpression of spermidine/spermine N1-acetyltranferase in transgenic mice protects the animals from kainate-induced toxicity.
27 Karjalainen JM et al. Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma.
28 Kemppainen S, Pitkänen A. Distribution of parvalbumin, calretinin, and calbindin-D28k immunoreactivity in the rat amygdaloid complex and colocalization with gamma-aminobutyric acid.
29 Kettunen MI et al. Interrelations of T1 and diffusion of water in acute cerebral ischemia of the rat.
30 Kivelä A et al. Gene therapy for atherosclerosis and restenosis.
31 Koistinaho J, Chan PH. Spreading depression-induced cyclooxygenase-2 expression in the cortex.
32 Kontkanen O et al. Molecular effects of the psychotropic NMDA receptor antagonist MK-801 in the rat entorhinal cortex: increases in AP-1 DNA binding activity and expression of Fos and Jun family members.
33 Kontkanen O et al. A functional genomic study of the effects of antipsychotic agent chlorpromazine in PC12 cells.
34 Koponen S. Expression of Protein Kinase C Subspecies after Cerebral Ischemia and Spreading Depression.
35 Koponen S et al. Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia.
36 Korhonen L et al. Expression of c-Met in developing rat hippocampus: evidence for HGF as a neurotrophic factor for calbindin D-expressing neurons.
37 Koskinen T et al. Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task.
38 Koskinen T et al. The 5-HT2 receptor activation enhances impulsive responding without increasing motor activity in rats.
39 Kossila M et al. Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase. Cloning, genomic structure, and screening for variants in patients with type 2 diabetes.
40 Kurkinen KMA et al. Genomic structure and chromosomal localization of the rat protein kinase Cdelta-gene.
41 Laakso MP et al. Hippocampus in Alzheimer´s disease: A 3-year follow-up MRI study.
42 Laitinen M et al. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty.
43 Lamusuo S et al. [11C]Flumazenil binding in the medical temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology.
44 Laukkanen J et al. Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradiation and foam-cell formation in macrophages.
45 Laukkanen MO et al. Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation.
46 Lehtolainen P et al. Retrovirus-mediated, stable scavenger-receptor gene transfer leads to functional endocytotic receptor expression, foam cell formation, and increased susceptibility to apoptosis in rabbit aortic smooth muscle cells.
47 Lehtonen J, Castrén E. Psykiatrian muuttuva viitekehys neurobiologian aikakaudella.
48 Lehtonen J, Castrén E. The changing framework of psychiatry in the era of neurobiology.
49 Lehtovirta M et al. A longitudinal quantitative EEG study of Alzheimer´s disease: relation to apolipoprotein E polymorphism.
50 Lindén A-M. Uncompetitive NMDA Receptor Antagonists: Insights into Their Pharmacological Actions via Alterations in Gene Expression Patterns in Rat Brain.
51 Lindén A-M et al. Expression of neurotrophins BDNF and NT-3, and their receptors in rat brain after administration of antipsychotic and psychotrophic agents.
52 Liubashina O et al. Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat.
53 Lukasiuk K, Pitkänen A. GABA(A)-mediated toxicity of hippocampal neurons in vitro.
54 Mikkonen M et al. Morphology of spiny neurons in the human entorhinal cortex: intracellular filling with lucifer yellow.
55 Mäkinen K et al. Adenovirus-mediated gene transfer into an experimental pancreatic tumour.
56 Mäkinen K et al. The growth pattern and microvasculature of pancreatic tumours induced with cultured carcinoma cells.
57 Mäkinen K et al. Evaluation of herpes simplex thymidine kinase mediated gene therapy in experimental pancreatic cancer.
58 Nieminen MT et al. Quantitative MR microscopy of enzymatically degraded articular cartilage.
59 Niittykoski M. Modulation of Synaptic Transmission and Behaviour by alpha2-adrenoceptors.
60 Niittykoski M et al. Diminution of N-methyl-D-aspartate-induced perturbation of neurotransmission by dexmedetomidine in the CA1 field of rat hippocampus in vitro.
61 Nissinen J et al. A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat.
62 Nuutinen J et al. Radiobiological depth of subcutaneous induration.
63 Pakkanen T, Ylä-Herttuala S. Gene therapy for dyslipidaemias.
64 Pakkanen TM et al. Periadventitial lacZ gene transfer to pig carotid arteries using a biodegradable collagen collar or a wrap of collagen sheet with adenoviruses and plasmid-liposome complexes.
65 Pitkänen A. Connectivity of the rat amygdaloid complex.
66 Pitkänen A et al. Anatomic heterogeneity of the rat amygdaloid complex.
67 Pitkänen A et al. Association between the density of mossy fiber sprouting and seizure frequency in experimental and human temporal lobe epilepsy.
68 Pitkänen A et al. Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat: a review.
69 Pulkkanen KJ et al. False-positive apoptosis signal in mouse kidney and liver detected with TUNEL assay.
70 Pulkkanen KJ et al. Characterization of a new animal model for human renal cell carcinoma.
71 Ruotsalainen S et al. Blockade of muscarinic, rather than nicotinic, receptors impairs attention, but does not interact with serotonin depletion.
72 Saarelainen T et al. Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia.
73 Saarelainen T et al. Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP.
74 Salmenperä T et al. MRI volumetry of the hippocampus, amygdala, entorhinal cortex, and perirhinal cortex after status epilepticus.
75 Salmenperä T et al. Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy.
76 Sandmair A-M. Gene Therapy for Malignant Glioma.
77 Sandmair A-M et al. Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
78 Sandmair A-M et al. Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
79 Sandmair A-M et al. Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.
80 Sandmair A-M et al. Adenoviruses as gene delivery vectors.
81 Storvik M et al. Induction of cAMP response element modulator (CREM) and inducible cAMP early repressor (ICER) expression in rat brain by uncompetitive N-methyl-D-aspartate receptor antagonists.
82 Turunen MP. Arterial Gene Transfer - New Methods and Safety Aspects.
83 Tuunanen J, Pitkänen A. Do seizures cause neuronal damage in rat amygdala kindling?
84 Vartiainen N. Novel Neuroprotective Effects of Cyclooxygenase Inhibitors - Cell Culture Studies Using a Hypoxia/Reoxygenation Injury Model.
85 Viita H, Ylä-Herttuala S. Effects of lipoxygenases on gene expression in mammalian cells.
86 Viluksela M, Ylä-Herttuala S. Eläinkokeet ja niiden vaihtoehdot.
87 Visted T et al. lacZ-neoR transfected glioma cells in syngeneic rats: growth pattern and characterization of the host immune response against cells transplanted inside and outside the CNS.
88 Vujcic S et al. Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs.
89 Wahlfors JJ et al. Evaluation of recombinant alphaviruses as vectors in gene therapy.
90 Ylä-Herttuala S, Martin JF. Cardiovascular gene therapy.
91 Ylä-Herttuala S et al. Oxidized low-density lipoproteins and atherosclerosis.
92 Yrjänheikki J et al. Spreading depression-induced expression of c-fos and cyclooxygenase-2 in transgenic mice that overexpress human copper/zinc-superoxide dismutase.
93 Yrjänheikki J. Cerebral Ischemia and Inflammation - Treatment with Minocycline.
94 Yrjänheikki J et al. Inhibition of inflammation and neuroprotection by tetracyclines.
95 Zachary I et al. Vascular protection. A novel nonangiogenic cardiovascular role for vascular endothelial growth factor.

A.I. Virtanen -instituutti A.I. Virtanen Institute for Molecular Sciences
Julkaisutietokanta 15.4.2008 Publications Data Base 15.4.2008