A.I. Virtanen -instituutti
A.I. Virtanen Institute for Molecular Sciences

Julkaisut 1999
Publications 1999

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1 Agrawal RS et al. Complement and anti-alpha-galactosyl natural antibody-mediated inactivation of murine retrovirus occurs in adult serum but not in umbilical cord serum.
2 Alafuzoff I et al. Beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients.
3 Alafuzoff I et al. Beta-amyloid load, astroglia and microglia in Alzheimer´s disease: association with apoE genotype.
4 Alhonen L et al. Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
5 Björklund M et al. Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns.
6 Castrén E, Lindholm D. Hermoston regeneraatio - lentääkö Teräsmies jälleen?
7 Gough PJ et al. Analysis of macrophage scavenger receptor (SR-A) expression in human aortic atherosclerotic lesions.
8 Gröhn OHJ et al. Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T1 in the rotating frame.
9 Haapalinna A et al. Comparison of the effects of acute and subchronic administration of atipamezole on reaction to novelty and active avoidance learning in rats.
10 Haapasalo A et al. Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells.
11 Hakumäki J. Characterization of Tissue Response in Cerebral Ischemia and Tumor Apoptosis. A Quantitative 1H NMR Spectroscopy Study.
12 Hakumäki JM et al. 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis.
13 Halonen T et al. Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat.
14 Heikkinen S et al. Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes.
15 Heitzer T et al. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both.
16 Helisalmi S et al. Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer´s disease patients and control individuals.
17 Hiltunen M et al. Linkage disequilibrium in the 13q12 region in Finnish late onset Alzheimer`s disease patients.
18 Hiltunen MO et al. Functional genomics and DNA array techniques in atherosclerosis research.
19 Hyttinen JM et al., inventor. Method for the production of biologically active polypeptides in a mammal's milk as fusion proteins that are less active than the free polypeptides, or non-active.
20 Häkkinen T et al. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, is expressed by macrophages in human and rabbit atherosclerotic lesions.
21 Hökfelt T et al. Galanin and NPY, two peptides with multiple putative roles in the nervous system.
22 Jolkkonen J et al. Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia.
23 Jongen-Rêlo AL et al. Distribution of GABAergic cells and fibers in the hippocampal formation of the macaque monkey: an immunohistochemical and in situ hybridization study.
24 Jäkälä P et al. Guanfacine, but not clonidine, improves planning and working memory performance in humans.
25 Jäkälä P et al. Clonidine, but not guanfacine, impairs choice reaction time performance in young healthy volunteers.
26 Jäkälä P et al. Guanfacine and clonidine, alpha2-agonists, improve paired associates learning, but not delayed matching to sample, in humans.
27 Jänne J et al. Genetic engineering of polyamine metabolism: consequences of the activation of polyamine biosynthesis or catabolism in transgenic rodents.
28 Karhunen LJ et al. Serum leptin and regional cerebral blood flow during exposure to food in obese and normal-weight women.
29 Kauppinen R, Kaila K. Neurobiologia tulevalla vuosituhannella: haasteita ja unelmia.
30 Keinänen R et al. Molecular cloning and characterization of the rat inducible nitric oxide synthase (iNOS) gene.
31 Koistinaho J et al. Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids.
32 Koistinaho J et al. Spreading depression-induced gene expression is regulated by plasma glucose.
33 Kontkanen O, Castrén E. Trophic effects of selegiline on cultured dopaminergic neurons.
34 Koponen S et al. Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
35 Korhonen V-P. Recombinant Proteins from Milk. Pilot Studies with Transgenic Mice Expressing Human GM-CSF and Erythropoietin.
36 Kryl D et al. Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells.
37 Kälviäinen R et al. Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual field defects.
38 Kälviäinen R, Pitkänen A. Prevention of seizure-induced neuronal damage and intellectual deterioration: experimental aspects and clinical implications.
39 Laitinen M. Gene Transfer to the Arterial Wall-Preclinical and Clinical Studies.
40 Lamusuo S et al. [18F]FDG-PET and whole-scalp MEG logalization of epileptogenic cortex.
41 Lang S et al. p53 gene mutations in neoplastic transformation of C3H 10T1/2 and severe combined immunodeficiency fibroblasts.
42 Laukkanen MO et al. Local hypomethylation in atherosclerosis found in rabbit ec-sod gene.
43 Lehesjoki A-E, Pitkänen A. Epilepsian geenit ja neurobiologia.
44 Lehtimäki T et al. Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease.
45 Lukkarinen J. A Nuclear Magnetic Resonance Study of Acute Cerebral Ischaemia Using Transgenic Rodents. Implications for a Neuroprotective Role of Ornithine Decarboxylase Activity.
46 Lukkarinen JA et al. Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat.
47 Luoma J, Ylä-Herttuala S. Sydän- ja verisuonisairauksien geenihoito.
48 Luoma JS, Ylä-Herttuala S. Expression of inducible nitric oxide synthase in macrophages and smooth muscle cells in various types of human atherosclerotic lesions.
49 Mäkimattila S et al. Autoantibodies against oxidized LDL and endothelium-dependent vasodilation in insulin-dependent diabetes mellitus.
50 Niittykoski M et al. Activation of muscarinic M3-like receptors and beta-adrenoceptors, but not M2-like muscarinic receptors or alpha-adrenoceptors, directly modulates corticostriatal neurotransmission in vitro.
51 Oja J. In Vivo Determination of Cerebral Hemodynamics and Bioenergetics Using Spin-Echo Magnetic Resonance Imaging.
52 Oja JME et al. Venous blood effects in spin-echo fMRI of human brain .
53 Oja JME et al. Determination of oxygen extraction ratios by magnetic resonance imaging.
54 Overmyer M et al. Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue.
55 Overmyer M et al. Astrogliosis and the ApoE genotype: an immunohistochemical study of postmortem human brain tissue.
56 Pakkanen T. Surgical Applications of Gene Therapy. An Experimental Study with Special Reference to Gene Transfer to the Liver and the Arterial Wall.
57 Pakkanen T, Ylä-Herttuala S. Gene therapy for atherosclerosis and atherosclerosis-related diseases.
58 Pakkanen TM et al. Improved gene transfer efficiency in liver with vesicular stomatitis virus G-protein pseudotyped retrovirus after partial liver resection and thymidine kinase-ganciclovir pre-treatment.
59 Pakkanen TM et al. Enhanced plasma cholesterol lowering effect of retrovirus-mediated LDL receptor gene transfer to WHHL rabbit liver after improved surgical technique and stimulation of hepatocyte proliferation by combined partial liver res...
60 Penttonen M et al. Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats.
61 Pikkarainen M et al. Projections from the lateral, basal, and accessory basal nuclei of the amygdala to the hippocampal formation in rat.
62 Pitkänen A, Jolkkonen J. Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
63 Pitkänen A et al. Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus.
64 Pitkänen A et al. Seizure-induced damage to the medial temporal lobe in temporal lobe epilepsy.
65 Poptani H et al. Diagnostic assessment of brain tumours and non-neoplastic brain disorders in vivo using proton nuclear magnetic resonance spectroscopy and artificial neural networks.
66 Pulkkinen A et al. The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients.
67 Pussinen R. An Experimental Study on the Role of alfa1-Adrenoceptors and Putrescine in the Modulation of Hippocampal Plasticity and Memory Encoding - Interactions with NMDA Receptors.
68 Pussinen R, Sirviö J. Effects of D-cycloserine, a positive modulator of N-methyl-D-aspartate receptors, and ST 587, a putative alpha-1 adrenergic agonist, individually and in combination, on the non-delayed and delayed foraging behaviour of rats .
69 Puumala T. Monoamines in the Modulation of Attention and Response Inhibition:Development of a New Animal Model of Attention Deficit and Impulsivity.
70 Rodriguez-Puertas R et al. Dopamine D1 receptor modulation of glutamate receptor messenger RNA levels in the neocortex and neostriatum of unilaterally 6-hydroxydopamine-lesioned rats.
71 Rothwell PM et al. Interpretation of operative risks of individual surgeons.
72 Rothwell PM et al. Prediction of benefit from carotid endarterectomy in individual patients: a risk-modelling study.
73 Ruponen M et al. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies.
74 Sandmair A-M et al. Low efficacy of gene therapy for rat BT4C malignant glioma using intra-tumoural transduction with thymidine kinase retrovirus packaging cell injections and ganciclovir treatment.
75 Sirviö J. Strategies that support declining cholinergic neurotransmission in Alzheimer's disease patients.
76 Sirviö J, MacDonald E. Central alfa1-adrenoceptors: their role in the modulation of attention and memory formation.
77 Sivenius J et al. Second European Stroke Prevention Study: antiplatelet therapy is effective regardless of age.
78 Sivenius J et al. Antiplatelet treatment does not reduce the severity of subsequent stroke.
79 Soininen HS, Riekkinen P Sr. APOE type and MRI volumetric changes as predictor of Alzheimer´s disease.
80 Suppola S et al. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a poly...
81 Tapiola T et al. Cerebrospinal fluid aspartate aminotransferase activity is increased in Alzheimer´s disease.
82 Tuomisto T et al. Psychological and physiological characteristics of sweet food "addiction".
83 Turunen M et al. Geeniterapia ja sen mahdollisuudet verisuonitautien hoidossa.
84 Turunen MP et al. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes.
85 Turunen MP et al. Gene therapy for angiogenesis, restenosis and related diseases.
86 Tuunanen J. Neuronal Damage in the Rat Amygdaloid Complex in Experimental Epilepsy . Distribution, Time Course, Mechanisms, and Prevention.
87 Tuunanen J et al. Status epilepticus-induced neuronal damage in the rat amygdaloid complex: distribution, time-course and mechanisms.
88 Törönen P et al. Analysis of gene expression data using self-organizing maps.
89 Ulatowski JA et al. In vivo determination of absolute cerebral blood volume using hemoglobin as a natural contrast agent: an MRI study using altered arterial carbon dioxide tension.
90 Usenius J-PR et al., inventor. Automated method for classification and quantification of human brain metabolism.
91 Vanhanen M et al. Type-2 diabetes and cognitive function in a non-demented population.
92 Vartiainen N et al. Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons.
93 Viita H et al. Different apolipoprotein B breakdown patterns in models of oxidized low density lipoprotein.
94 Viita H et al. High expression of human 15-lipoxygenase induces NF-kappaB-mediated expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and T-cell adhesion on human endothelial cells.
95 Väisänen J et al. Excitatory actions of NMDA receptor antagonists in rat entorhinal cortex and cultured entorhinal cortical neurons.
96 Ylinen A et al. Long-term treatment with vigabatrin - 10 years of clinical experience.
97 Ylitalo R et al. Metabolism of modified LDL and foam cell formation in murine macrophage-like raw 264 cells.
98 Ylä-Herttuala S. Vascular gene therapy - early clinical results with angiogenic growth factors.
99 Ylä-Herttuala S. Oxidized LDL and atherogenesis.
100 Ylä-Herttuala S. Pathogenesis and treatment of atherosclerosis-related diseases: challenges for vascular biology in the next millennium.
101 Yrjänheikki J et al. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.
102 Äikiä M et al. Predictors of seizure outcome in newly diagnosed partial epilepsy: memory performance as a prognostic factor.

A.I. Virtanen -instituutti A.I. Virtanen Institute for Molecular Sciences
Julkaisutietokanta 15.4.2008 Publications Data Base 15.4.2008